The voice and facial motion capture of Detective Pikachu, a world-class detective and exceptionally smart Pikachu whom only Tim can understand.

provides Detective Pikachu's normal voice as heard by humans other than Tim.

A former Pokémon trainer looking for his missing father; he is also Detective Pikachu's partner, and the only person capable of hearing him speak.

A reporter who is accompanied by a Psyduck.

A Pokémon trainer who runs a battle arena for Pokémon and is accompanied by a Charizard.

Howard's son and president of Clifford Enterprises.

A veteran Ryme City police lieutenant and friend of Harry who is accompanied by a Snubbull.

The visionary behind Ryme City.

Tim's friend who is a Pokémon trainer.

A scientist.